Enhanced osteoblastogenesis in three-dimensional collagen gels
نویسندگان
چکیده
منابع مشابه
The micromechanics of three-dimensional collagen-I gels
We study the micromechanics of collagen-I gel with the goal of bridging the gap between theory and experiment in the study of biopolymer networks. Three-dimensional images of fluorescently labeled collagen are obtained by confocal microscopy and the network geometry is extracted using a 3d network skeletonization algorithm. Each fiber is modeled as a worm-like-chain that resists stretching and ...
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BACKGROUND Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes contract and degrade three-dimensional collagen gels in extended co-culture"). The current study, therefore, was designed to evaluate production of matrix-degrading metalloproteinases by these cells in co-culture...
متن کاملNormal human primary fibroblasts undergo apoptosis in three-dimensional contractile collagen gels.
Apoptosis of primary fibroblasts was observed in vivo during wound healing in skin and is expected to occur in other organs as well; however, the environmental signal for induction of apoptosis in fibroblasts and the putative influence of cell-matrix interactions on the regulation of apoptosis remain to be identified. Here we provide evidence for the role of fibrillar collagen in this process, ...
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BACKGROUND Inflammatory cells are believed to play a prominent role during tissue repair and remodeling. Since repair processes develop and mature over extended time frames, the present study was designed to evaluate the effect of monocytes and fibroblasts in prolonged culture in three-dimensional collagen gels. METHODS Blood monocytes from healthy donors and human fetal lung fibroblasts were...
متن کاملCNS stem and progenitor cell differentiation into functional neuronal circuits in three-dimensional collagen gels.
The mammalian central nervous system (CNS) has little capacity for self-repair after injury, and neurons are not capable of proliferating. Therefore, neural tissue engineering that combines neural stem and progenitor cells and biologically derived polymer scaffolds may revolutionize the medical approach to the treatment of damaged CNS tissues. Neural stem and progenitor cells isolated from embr...
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ژورنال
عنوان ژورنال: Bonekey Reports
سال: 2014
ISSN: 2047-6396
DOI: 10.1038/bonekey.2014.55